tag:blogger.com,1999:blog-4503292949532760618.post8146436661129465132..comments2024-03-28T07:23:23.408-07:00Comments on DSHR's Blog: Cost-Reducing Writing DNA DataDavid.http://www.blogger.com/profile/14498131502038331594noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-4503292949532760618.post-44860781701813204712019-05-29T20:28:44.761-07:002019-05-29T20:28:44.761-07:00Tom Coughlin reports on Iridia's chip-based DN...Tom Coughlin reports on <a href="https://www.forbes.com/sites/tomcoughlin/2019/05/22/dna-data-strands/#4786318a35f1" rel="nofollow">Iridia's chip-based DNA storage technology</a>.David.https://www.blogger.com/profile/14498131502038331594noreply@blogger.comtag:blogger.com,1999:blog-4503292949532760618.post-90890924419308965692019-03-26T13:38:34.704-07:002019-03-26T13:38:34.704-07:00The team from Microsoft Research and U.W. have a ...The team from Microsoft Research and U.W. have a <a href="https://doi.org/10.1038/s41598-019-41228-8" rel="nofollow">paper</a> and a <a href="https://www.youtube.com/watch?v=60Gi5lqL-dA&feature=youtu.be" rel="nofollow">video</a> describing a fully-automated write-store-read pipeline for DNA. This is, I believe, a first automated end-to-end demonstration. From their abstract:<br /><br />"Our device encodes data into a DNA sequence, which is then written to a DNA oligonucleotide using a custom DNA synthesizer, pooled for liquid storage, and read using a nanopore sequencer and a novel, minimal preparation protocol. We demonstrate an automated 5-byte write, store, and read cycle with a modular design enabling expansion as new technology becomes available."<br /><br />Their system is base-at-a-time, so it is still slow:<br /><br />"Our system’s write-to-read latency is approximately 21 h. The majority of this time is taken by synthesis, viz., approximately 305 s per base, or 8.4 h to synthesize a 99-mer payload and 12 h to cleave and deprotect the oligonucleotides at room temperature. After synthesis, preparation takes an additional 30 min, and nanopore reading and online decoding take 6 min."<br /><br />Again, this is a significant step forward, but a practical product is a long way away.David.https://www.blogger.com/profile/14498131502038331594noreply@blogger.com